Despite extraordinary scientific progress, there are still no effective vaccines for HIV/AIDS, TB, and malaria.
Our goal is to make transformative advances to accelerate progress towards vaccines, drugs, and diagnostics for these infectious diseases.
We pioneered systems biology approaches to infectious disease research that we believe will allow us to drastically shorten the time to discovery.
Our approach is to examine the interactions of pathogens and hosts on a comprehensive scale.
We bring the most advanced scientific approaches to confront the challenges of infectious disease.
Solving the mysteries between pathogens and the immune system will require an inter-disciplinary approach. At the Center for Infectious Disease Research, scientists, mathematicians, technologists, engineers, and physicians collaborate in the scientific process.
We work tirelessly with over 140 collaborators across 25 countries.
Over the next ten years we look to advance the science to prevent, treat, and cure HIV/AIDS, TB, malaria, and other emerging infectious diseases.
Discover the impact of our science.There is hope
Our research aims to make transformative advances that lead to the prevention and treatment of infectious diseases.
The Center’s singular focus on global infectious diseases and its integration of systems biology uniquely positions us in the fight against infectious diseases.
Why Systems Biology?
The Center develops and employs systems biology approaches to accelerate progress in the development of vaccines to prevent, drugs to treat, and diagnostics to detect lethal and debilitating infectious diseases.
Systems biology addresses that fact that all components of living cells and organisms work together as a unit. In biology, like in any complex system, the “whole” is greater than the sum of its parts. In biology, the characteristics that emerge from the combined properties and interactions of the component parts include growth and reproduction of cells and organisms, consciousness, and cognition. In the case of an infectious disease, there is a complex interplay between the infectious agent and the human host.
Systems biology allows us to discover the workings of the infectious agents and how they cause disease and how the host responds to defend itself from infection. With this knowledge, we can develop vaccines to prevent infection or disease or discover drugs to cure the infection.
What is Systems Biology?
Advances in laboratory technologies and computing have recently progressed to a level that allows us to investigate, in a comprehensive manner, infectious disease problems. Thus, systems biology exploits sophisticated ‘omics (e.g. proteomics, genomics, transcriptomics, etc.) and other technologies to identify and quantify all molecular elements at play in both the pathogen and the host during an infection. Statistical and computational approaches are used to integrate that information into graphical network models that represent the complex and dynamic molecular interactions underlying the battle. Mathematical equations and formulae in computer algorithms are then used to explain and predict the system's emergent behaviors and to design changes to the system that will tip the balance in favor of the host.
The systems biology approach offers a comprehensive look at the interactions between pathogen and host. Through this extensive view, we can use algorithms to identify changes that favor the host. This becomes the foundation for rational designs for vaccines and drugs.Learn More