A biopsy technique is described that has been used in my clinical practice thousands of times. This very simple, cost-effective technique employs only one surgical tool, the scalpel blade, and permits a biopsy to be taken with sufficient tissue for histologic analysis. In that there is no disruption of a tumor margin, it permits the physician to make a diagnosis and not limit his or her choice of therapeutic modalities. Again, I wish to stress that appropriate selection of lesions is a critical point of this technique. It is unacceptable for lesions suspected to be malignant melanoma or for dermatoses that may have a deep component.