Major grant renewed for immune system investigation

Aderem Lab announces major grant renewal for long-standing exploration of the immune system

Dr. Alan Aderem

September 2017―The Aderem Lab, renowned for their use of systems biology to uncover a deeper understanding of the immune system, is part of a multidisciplinary U19 grant recently renewed by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. The $11.2 million grant is designed to generate and computationally analyze large-scale, unbiased datasets to reveal previously unknown regulators of the innate immune system response to infection or vaccination.

A deeper and more precise understanding of the immune system is critical to designing better vaccines, therapies, and diagnostics for infectious diseases. This knowledge is particularly important for diseases that affect resource-poor countries such as HIV/AIDS , tuberculosis and malaria. As such, this 15-year-long project is a critical investment in basic research of the immune system.

This was a highly competitive renewal – only three awards were made in response to a vast number of applications for this round of funding, a testament to the impressive record of work by CID Research and its partners. This particular grant is unique in that it brings together researchers from diverse discipline, including immunology, computational biology, medicine, engineering and physics, to combine their expertise in pursuit of a shared question.

The grant is designed to bring together leading researchers with complementary expertise to tackle fundamental questions in immunology. Alan Aderem, Ph.D. (pictured), is the principal investigator at CID Research and a world-renowned pioneer in systems biology and innate immunology. The overarching program is led by Richard Ulevitch, Ph.D., Principal Investigator at the Scripps Research Institute. Co-investigators include: Nobel laureate Bruce Beutler, M.D., of UT Southwestern, an expert in mouse genetics; and Garry Nolan, Ph.D., of Stanford University, an expert in technology development.

The work of the Aderem Lab is highly complementary to research on specific viral or bacterial pathogens, as the innate immune system is engaged against all of these microbes. While this program is focused on infectious disease, it will uncover and decipher fundamental immune mechanisms that regulate inflammation in other diseases such as autoimmunity, heart disease and cancer, and thereby inform the development of therapies for these conditions as well.

The grant number is U19AI100627.


The Center for Infectious Disease Research is the largest independent, non-profit organization in the U.S. focused solely on infectious disease research. Our research is the foundation for new drugs, vaccines and diagnostics that benefit those who need our help most: the fourteen million who will otherwise die each year from infectious diseases, including malaria, HIV/AIDS and tuberculosis. Founded in 1976, CID Research partners with key collaborators around the globe and strives to make discoveries that will save lives. For more information, visit



See more CID Research News & Press