Professor & Scientific Director, Seattle Biomedical Research Institute
Affiliate Professor, Department of Global Health, University of Washington
Area of Expertise: HIV/AIDS, immunology, vaccinology
The emphasis of Leo Stamatatos’ work is to develop a safe and effective vaccine to combat the spread of HIV and to investigate how HIV infection leads to AIDS.
A major area of interest for Stamatatos' lab is to better understand how neutralizing antibodies against HIV are developed during natural HIV-infection, in a subset of individuals infected with HIV. They are particularly interested in:
- identifying immunological pathways that lead to the development of broadly neutralizing antibodies during natural HIV infection and exploit these pathways for vaccine-related purposes
- understanding how the virus evolves to avoid the action of such antibodies
The Stamatotos group utilizes diverse approaches and iterative methodologies to design and test candidate HIV vaccines
- HIV envelope structure/function relationship
- B cell immunology in the conext of HIV infection
- HIV evolutionary escape pathways and pathogenesis
- HIV vaccine design
Stamatatos’ research is currently supported by the National Institutes of Health (NIH).