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Andrew V. Oleinikov, Ph.D.

Principal Scientist/Independent Lab, Seattle Biomedical Research Institute
Area of Expertise: malaria

Publications

2013

Antibodies to E.coli expressed C-terminal domains of Plasmodium falciparum VAR2CSA inhibit binding of CSA-adherent parasites to placental tissue

2012

Preclinical evaluation of pregnancy malaria vaccine immunogens: a multi-laboratory approach

A survey of naturally acquired antibody responses to 38 PfEMP1 domains in plasma of Tanzanian infants reveals frequent recognition of VAR2CSA

2009

High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 P. falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodies

2008

VAR2CSA domains expressed in Escherichia coli induce cross-reactive antibodies to native protein

Thoughts on placental malaria vaccine epitopes — pregnant but premature. Reply to Beeson et al.

VAR2CSA domains expressed in E.coli induce cross-reactive antibodies to native protein

2007

Six genes are preferentially transcribed by the circulating and sequestered forms of Plasmodium falciparum parasites that infect pregnant women

Effects of gender, parity and sequence variation on seroreactivity to candidate pregnancy malaria vaccine antigens

2005

RNA interference by mixtures of siRNAs prepared using custom oligonucleotide arrays

2004

Immunoassays Based on Electrochemical Detection Using Microelectrode Arrays

The adaptor Disabled-2 binds to the third ?xNPxY sequence on the cytoplasmic tail of Megalin

2003

Self-assembling protein arrays using electronic semiconductor microchips and in vitro translation

2001

Functional characterization of rat gp600/megalin promoter: combination of proximal Sp1 site and JCV repeat is important in rat gp600/megalin promoter activation

2000

Increased expression of cytoplasmic tail-containing form of gp600/megalin in active Heymann nephritis

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytotic receptor megalin

A small 60 kDa fragment of gp600/megalin, major autoantigen of active Heymann nephritis of rat, can induce full-blown disease

1998

A single-headed dimer of E coli ribosomal protein L7/L12 supports protein synthesis

1997

Localization of two domains of a mutant form of Escherichia coli protein L7/L12 that binds the large ribosomal subunit as a single dimer

1996

Rotational and conformational dynamics of Escherichia coli ribosomal protein L7/L12

Dimer/Monomer equilibrium and domain separations of Escherichia coli ribosomal protein L7/L12

Tetramethylrhodamine dimer formation as a spectroscopic probe of the conformation of Escherichia coli ribosomal protein L7/L12 dimers

1995

Location and domain structure of Escherichia coli ribosomal protein L7/L12: site-specific cystein crosslinking and attachment of fluorescent probes

The Hinge Region of Escherichia coli Ribosomal Protein L7/L12 Is Required for Factor Binding and GTP Hydrolysis

Different molecular forms of rat kidney gp330 - major autoantigen in active Heymann nephritis

1993

Structural and functional domains of E.Coli ribosomal protein L7/L12. The hinge region required for activity

Escherichia ribosomal protein L7/L12 dimers remain fully active after interchain crosslinking of the C-terminal domains in different orientations

Zero-length crosslinking of the C-terminal domain of E.coli ribosomal protein L7/L12 to L10 in the ribosomeand in the (L7/L12)4-L10 pentameric complex

1992

The C-terminal domain of E.coli ribosomal protein L7/L12 can occupy a location near the Factor-binding domain of the 50S subunit as shown by cross-linking with N-[4-(p-Azidosilicylamido)butyl]-3-(2'-pyridyldithio) propion- amide

The proximity of the C-terminal domain of E.coli ribosomal protein L7/L12 to L10 determined by Cysteine site-directed mutagenesis and protein-protein cross-linking

1991

Primary structure of the cDNA 5'-terminal region encoding the N-terminal domain ofthe rabbit muscle a-actinine subunite

1989

Evidence for the appearance of a reticulocyte population low in lipoxigenase mRNAduring the recovery from a phenylhydrazine-induced anemia an rabbits

Primary structure of rat liver elongation factor 2 deduced from the cDNA sequence