Dr. Oleinikov is heading one of Seattle BioMed's malaria research laboratories. Together with former Seattle BioMed principal investigators Drs. Patrick Duffy and Michal Fried (both now working at NIAID/NIH), Oleinikov manages a collaborative research program on malaria pathogenesis and immunity. This program hosts two international consortia to study pregnancy malaria and children’s malaria, with funds from the Bill & Melinda Gates Foundation and the Grand Challenges in Global Health.
The work of the Oleinikov lab is extended from Seattle to field labs in Africa. Human research on malaria is performed through a field research program in Tanzania, which was established by Drs. Fried and Duffy together with Tanzanian scientists.
Research
The Oleinikov lab studies malaria parasite biology and virulence factors. Primary research objectives include developing a pregnancy malaria vaccine, understanding immunity to severe malaria in children, identifying targets for a sterilizing vaccine that targets liver stage parasites, and developing various technologies for malaria research.
Some of the scientific approaches of the research team include high throughput functional protein array platforms to survey protective immune responses, high throughput RNA sequencing, small molecule library screening to identify anti-adhesion drugs, plasma proteome mass spectral analysis to identify disease biomarkers of severe maternal anemia, and immunofluorescence microscopy to study biology and pathophysiology of P. falciparum.
Scientific partners include scientists at National Institutes of Health, Centers for Disease Control and Prevention, University of Washington, University of California – Davis, University of Copenhagen, Pasteur Institute – Paris, Johns Hopkins Malaria Research Institute, and Sharp Laboratories of America.
Support for Oleinikov's work is provided by the Bill & Melinda Gates Foundation, Grand Challenges in Global Health and National Institutes of Health.
Biography
Education
Ph.D. Biology Moscow State University, Moscow, USSR
M.S. Engineering Physics Leningrad Polytechnical University, Leningrad, USSR
Professional Experience
- Principal Scientist, Malaria Program, Seattle Biomedical Research Institute, 2004-present
- Principal Scientist, CombiMatrix Corporation, 2000-2003
- Research Assistant Professor, Department of Pediatrics, Division of Nephrology, School of Medicine, University of California - Davis, 1997-2000
- Postdoctoral Fellow, Department of Pediatrics, Division of Nephrology, School of Medicine, University of California - Davis, 1995-1996
- Postdoctoral Fellow, Department of Biological Chemistry, School of Medicine, University of California - Davis, 1991-1995
- Research Scientist, Protein Chemistry Lab, Institute of Protein Research, Russian Academy of Science, 1988-1991
- Graduate Student, Protein Chemistry Lab, Institute of Protein Research, Russian Academy of Science, 1985-1988
- Research Associate, Protein Chemistry Lab, Institute of Protein Research, Russian Academy of Science, 1983-1985
Professional Societies
- American Society for Cell Biology, 2002
- American Society for Tropical Medicine and Hygiene
Staff
Bob Morrison, Bioinformatics Lab Manager
Gladys Keitany, Post-doctoral Scientist
Justin Gullingsrud, Research Technician II
Kara Blaisdell, Laboratory Assistant
Kathryn Williamson, Research Technician II
Mike Gagliano, Laboratory Technician
Neta Milman, Post-doctoral Scientist
Richa Chaturvedi, Research Technician II
Sharon Wong-Madden, Senior Project Manager
Shu Dong, Post-doctoral Scientist
Tina Chu, Research Technician II
Tracy Saveria, Post-doctoral Scientist
Zachary MacMillen, Research Technician II
